Obama tailors election-year message to working women

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Time for Nick Clegg and the Coalition to see sense and stop the ...

This year?s budget was, in general, a good one for Lib Dems. Most notably, the party?s number one priority of taking more low-paid workers out of tax was fast-tracked, while the controversies, and specifically the cut in the 50p top-rate at a time when pensioners? tax allowances are being frozen, have hit their Tory backers? support in the polls.

However, there is one lesser noticed and malign Budget change, the ?Charity Tax? ? a cap on tax relief which threatens to cost the charitable sector hundreds of millions of pounds ? which has not attracted mainstream media attention. That needs to change if the Coalition is to be talked down from a policy with Lib Dem fingerprints on it, and which will undermine philanthropic giving at a time when it is needed more than ever during the public funding squeeze.

What the ?Charity Tax? is

?What is the ?Charity Tax??? you ask. Well, the harsh truth is it?s Nick Clegg?s fault. Why? Because the ?Charity Tax? is a direct consequence of the ?Tycoon Tax? which Nick personally championed in return for the Tories? wish to cut the 50p tax-rate. The ?Tycoon Tax? is a justifiable and progressive attempt to clamp down on the excessive use of tax-reliefs which often result in the very wealthiest having a lower overall rate of tax than the rest of us.

But there is an unintended consequence of the ?Tycoon Tax?, and it?s this: because it will also cap the tax-relief on charitable giving available to wealthy philanthropists many will end up scaling back their generosity. For the details of the tax changes I recommend this Charities Aid Foundation article ? but the following example illustrates the problem:

Felicity Culture-Vulture earns ?800K and is a 45%-rate taxpayer . She makes a lump sum gift of ?1m to a local museum to help build a new education centre. Through Gift Aid the donation is worth ?1.25m to the museum after basic rate tax has been reclaimed. Under current rules, Ms Culture-Vulture is then able to claim back ?312.5K in personal tax relief for herself, which she plans to give to other causes. However, under the new rules, her tax relief would be capped at 25% of ?800K, i.e. ?200K. This means that she (and the other causes she supports) would lose out on a potential ?112.5K.

Why tax relief matters to good causes

Some folk tend towards the cynical when it comes to philanthropy (I?ve a sneaking suspicion some of them work for HM Treasury), so I?d like to tackle two questions often thought if not always spoken out loud?

1) ?Isn?t this just another form of tax avoidance??
Simple answer: no. It is absolutely impossible under UK tax law to make a financial gain by giving money away to charity. In the example above, ?Ms Culture-Vulture? did not benefit financially ? she voluntarily opted to become worse off to the net tune of ?487.5k, a sum she was under no obligation to hand over. The beneficiary was the charity and those who will enjoy its services.

2) ?Are you saying philanthropists only give because there?s tax relief??
Simple answer again: no. Tax relief is not why wealthy people donate: like the rest of us who give to charities they are motivated by supporting a cause they believe in. But tax relief is a strong driver of how much they feel able to afford to give.

I sense there may still be some sceptics who shrug, and say ?Tough, they?re wealthy enough, they should just dig deeper in their pockets if they?re really passionate about their philanthropy.? And I?m sure there will be many philanthropists who do precisely that. But realistically there will be others who choose not to, and who will reduce their charitable giving because they believe they can no longer afford (relatively speaking) to give as much as they can under the current system. If so, the wealthy won?t be any worse off; charity beneficiaries will be.

Initial estimates (and they are only that) suggest good causes could lose out substantially. This statistic shows why: of the ?11 billion given to charity last year, almost half was donated by just 7% of donors.

The Lib Dems and the ?Charity Tax?

Six months ago I posed the question here, ?What is the Lib Dem position on ?The Big Society??? ? and was forced to conclude that the party didn?t really have one. That gap has become much more apparent in the last fortnight.

What I suspect happened in the budget negotiations is this (this at any rate is how I?ve rather shamefacedly explained it to my colleagues in the charitable sector who?re curious why the Lib Dems are so keen on the ?Charity Tax?)?

Rather late in the day, Nick Clegg and his advisers hit on the idea of the ?Tycoon Tax? in exchange for dropping the Lib Dems? opposition to the 50p rate. Even later in the day, someone noticed that charitable giving would be caught in the crossfire. So a caveat was hastily inserted promising ?the Government will explore with philanthropists ways to ensure that this measure will not impact significantly on charities that depend on large donations.? The Treasury is now into its formal 90-day consultation mode, and met with charity campaigners this week. With luck ? and with pressure ? they may see sense and exempt charitable giving from the tax-relief clampdown. The current mood music is not encouraging, however; once the Treasury sniffs revenue they are doggedly tenacious in keeping it ? ?entrenched? is the word I?ve heard used to describe their attitude.

I don?t mind whether it?s called the Big Society, civil society, or the third or charitable sector ? what I do know is that it depends on philanthropic giving, on private individuals choosing to give away their money. For the sake of all good causes the ?Charity Tax? needs to be stopped.

To show your support for the ?Give it back George? campaign for the Government to drop the charity tax, please visit this site and sign the petition.

Full disclosure: I?m a full-time fundraiser who?s been working for educational charities since 1998.

* Stephen Tall is Co-Editor of Liberal Democrat Voice, and also writes at his own site, The Collected Stephen Tall.

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Organising Your Email Marketing Campaign

If you have just recently decided to try implementing an email marketing program, you can congratulate yourself on becoming involved in one of the best kinds of web based promoting for your business. While many entrepreneurs have a tendency to back away from e-mail promotional campaigns because they suspect these campaigns are always viewed as spam, others realize the significance of this sort of advertising and are willing to spend a good deal of time and effort into organising their email promotional campaign. These entrepreneurs will likely find they are able to enjoy an edge over their competitors who do not spend a little time to implement amail marketing campaign. This text will describe the steps important to organise a useful email marketing program. Organizing my Houston Truck Accident Lawyers site for email marketing is my first step..

One of the first elements you must consider when you make the choice to start an e-mail marketing campaign is the sort of information you would like to include in your e-mails to potential customers. This is vital as the information you provide will help your e-mail recipients to ascertain irrespective of whether or not they think your products or services are worth it. You can include a range of information in selling mails. This may include, but is not restricted to, full length educational articles, brief articles enticing readers to go to your website to get some more information, links to other web sites which may be interesting to your fans, links to your own website and even ads for your products as well as other products or services your customers may appreciate.

When you decide the kind of content you want to include into your e-mail marketing, it's time to think about how you need to structure your e-mail promotional efforts. A couple of the most common structures include an educational email with subtle advertising or an in depth e-newsletter with a plethora of info as well as some sophisticated advertising and even some graphics. Deciding on the format of the mails you will be sending out are important because they can dictate the staff you'll need to help you in your e-mail selling effort. You may require the help of a pro writer to help you with the content in either e-mails or e-newsletters but if you choose an e-newsletter you need to also contemplate hiring a graphic artist to help you in designing an attractive layout and making graphics as wanted to create an intriguing layout for your e-newsletter.

Next you must reflect upon how you plan to create an email distribution list. This is important because simply purchasing an e-mail list is unlikely to be useful. You will reach hundreds, thousands or even millions of Internet users by sending e-mails to all the members of this email list but there is no guarantee any of them will have a healthy interest in your goods. Nevertheless if you build your own e-mail list of prior buyers who have especially requested extra information as well as future client who've also requested additional information you will have a well formulated list which includes generally members of your target audience. This is excellent because you're much likelier to sell products or services to members of your audience than you are to sell goods and services to members of an e-mail group which isn't full of those that might be interested in the goods and services you offer.

Once all of these initial decisions have been made, you can start to create the mails themselves and can start to disburse these e-mails. After you have sent out your first crop of emails, you can take a while to appraise the effectiveness of the first e-mail before you send out the second batch. This will be handy because if you determine the 1st batch was not particularly successful you can seek feedback and make changes to the second e-mail before sending it out. If the second e-mail is more successful than the 1st, you can conclude the changes you made were constructive.

Read up about Houston accident attorney and Houston truck accident attorneys articles. The author is Allan Gonzaga.

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Clay County Wins State Farm Business Management Contest ...

Members of the Clay County FFA Chapter won first-place in the Tennessee Association FFA Farm Business Management Career Development Event during the 84^th Tennessee State FFA Convention on April 4.

This team will represent Tennessee in the National Farm Business Management Career Development Event at the National FFA Convention in October. The Clay County member?s agricultural education instructors and FFA advisors are Jason Coons and Beth Hatcher.

The Farm Business Management CDE is designed to test the ability of students to apply economic principles and concepts in analyzing farm and ranch business management decisions. Participants respond to questions concerning economic principles in farm business management as well as a problem-solving analysis section. Farm Credit Services of Mid-America sponsored a cash award for expenses related to participation in the national contest.

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Promising vaccine targets on hepatitis C virus

ScienceDaily (Apr. 3, 2012) ? A team led by scientists at The Scripps Research Institute has found antibodies that can prevent infection from widely differing strains of hepatitis C virus (HCV) in cell culture and animal models.

HCV's very high rate of mutation normally helps it to evade its host's immune system. The newly discovered antibodies, however, attach to sites on the viral envelope that seldom mutate. One of the new antibodies, AR4A, shows broader HCV neutralizing activity than any previously reported anti-HCV antibody.

"These antibodies attach to sites on the viral envelope that were previously unknown, but now represent promising targets for an HCV vaccine," said Mansun Law, an assistant professor at Scripps Research. Law is the senior author of the new report, which appears online this week in the Proceedings of the National Academy of Sciences.

A Desperate Need

An effective HCV vaccine is desperately needed. The World Health Organization (WHO) estimates that the virus has established mostly silent infections in 130 to 170 million people worldwide -- nearly 3 percent of the human population -- and spreads to 3 to 4 million new people annually. HCV principally infects liver cells, and is thought to cause chronic, often-unnoticed liver inflammation, which eventually can lead to serious liver ailments. The virus already is responsible for about a quarter of annual US cases of liver cirrhosis and primary liver cancer, and it is the leading cause of liver transplants. In some developing countries, HCV prevalence is extremely high; studies suggest that in Egypt, as many as 22 percent of the population is infected -- apparently due to poor screening of blood products and past re-use of syringes. Even in developed countries, HCV infections represent a looming public health crisis. In the United States and Europe, up to 14 million people are now HCV-positive, and each year an estimated 150,000 people are newly infected.

The current leading treatment for HCV infection involves a 12- to 36-week course of the immune-stimulating protein interferon-alpha, the antiviral drug ribavirin and HCV protease blocker. But it is not completely effective, and it causes significant adverse side effects -- aside from being very expensive. To fully stamp out the HCV pandemic, especially in developing countries, scientists will have to develop a cheap preventive vaccine.

Yet an effective HCV vaccine has so far been elusive. The virus mutates very rapidly, and thus, antibodies raised against one isolate of HCV typically won't protect against a subsequent HCV infection. Hospital samples of HCV suggest that the virus's genes, and the proteins for which they code, are highly variable even within an individual patient.

"One of the big goals of HCV vaccine development has been to find an accessible spot on the virus that doesn't change constantly," said Law.

Searching for Vulnerabilities

To find such vulnerable spots, researchers sift through antibodies sampled from infected people and look for those antibodies that can neutralize a broad range of viral strains. The locations on the virus where those broadly neutralizing antibodies bind mark the vulnerable viral structures that can be used as the bases of a broadly effective, antibody-stimulating vaccine. Previous studies, including a 2008 study in Nature Medicine, for which Law was lead author, have found some broadly neutralizing HCV antibodies. But for the present study, Law and his colleagues used a more thorough approach, known as "exhaustive panning," to see if they could find new and even more broadly neutralizing antibodies. "Exhaustive panning is a powerful technique for finding rare antibodies that might otherwise go undetected," Law said.

HCV employs a complex of two envelope glycoproteins, E1 and E2, to grab and fuse with target cells. Erick Giang, a research assistant in Law's lab, harvested this viral E1-E2 complex from HCV-producing cells in a lab dish and used it as "bait" for a panel of antibodies derived from the blood of a person with chronic HCV infection. The exhaustive panning technique involves exposing this bait protein to different anti-HCV antibodies in sequence, so that the known antibody-binding sites on the complex are progressively covered until only new ones are left.

In this way, Giang catalogued 73 new anti-HCV antibodies, which bind to five distinct "antigenic regions" on the E1-E2 complex. In standard cell culture tests of HCV-neutralizing ability, several of these antibodies showed an ability to neutralize infection by a wide range of HCV strains. One, AR4A, turned out to bind to an almost-unvarying spot on E1-E2 complex, close to the surface of the virus's outer coat of fat molecules. AR4A showed significant neutralizing ability against all 22 HCV strains in a test panel -- not only in tests in Law's lab, but also in confirmatory tests at the University of Copenhagen.

The Broadest Neutralizing Activity Yet

The new antibody thus is more broadly protective than the previous top contender, AR3A, which Law described in his 2008 Nature Medicine paper. "This human antibody AR4A has the broadest HCV-neutralizing activity known to the field," Law said.

Collaborating researchers at Rockefeller University, who recently engineered a line of HCV-infectable mice, showed that AR4A antibodies protected these mice from two widely different HCV strains. A combination of half-doses of AR3A and AR4A antibodies worked less well.

The next step for Law and his colleagues is to start making and testing prototype vaccines based on the vulnerable HCV binding sites that have been revealed by these antibody studies. The researchers also plan to use the new antibodies to study the structure and function of HCV proteins such as the all-important E1-E2 complex.

Anti-HCV antibodies such as AR4A and AR3A could have some therapeutic use, too. Although they wouldn't be able to clear existing HCV infections and would be too expensive and difficult to use on a large population to prevent new infections, they could be useful in preventing new HCV liver infections in liver transplant patients. Such infections can spread from HCV reservoirs in the patient's body to the newly transplanted liver tissue.

"Antibody-based treatment has worked extremely well for liver transplants to patients with hepatitis B virus, and we hope the new HCV antibodies can be just as helpful to HCV liver transplant patients," Law said.

In addition to Law and Giang, contributors to the paper, "Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus," were Marcus Dorner, Charles M. Rice, and Alexander Ploss of Rockefeller University in New York; Jannick C. Prentoe and Jens Bukh of the University of Copenhagen; Matthew J. Evans of the Mount Sinai School of Medicine; and Marl?ne Dreux and Dennis Burton at Scripps Research.

The Law laboratory's research is supported by the National Institutes of Health.

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The above story is reprinted from materials provided by Scripps Research Institute.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Microsoft launches Kinect Star Wars in India for Rs. 2399 - Video ...

Gamer?s dreams of waving their hands in front of the TV pretending to be a Jedi Knight can finally come true. Microsoft has launched a Star Wars game that is playable with its motion-controlled sensor, Kinect, in India. The game is an XBOX 360 exclusive and gamers can pick it up for Rs. 2,399.

In a statement, Microsoft said, ?This new title will add to the growing popularity of the family-friendly gaming portfolio for Kinect for Xbox 360.?

In the game, gamers can wave their hands in front of the TV to use the Lightsaber (the Jedi?s preferred weapon of choice) to attack, use the force to maneuver objects and take down enemies, participate in Pod races and even make Han Solo dance in a mini-game. The game also takes players into outer space for a galactic Dog Fights. All these variations in gameplay are controlled with gestures only. Gamers do not require a physical controller to maneuver the actions on screen.

Kinect Star wars is just one of the most awaited gaming titles to hit store shelves this month. If you are in the market to pick up a bunch of games, read? our list of top 5 console games launching in April.

Kinect Star Wars was originally shown off as a tech demo behind closed doors two years ago at E3. The game has finally seen the light of day. Has it lived up to fans expectations? Stay tuned as we will bring you a review of the game soon.

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news: Why Giving Away FREE Ebooks Can Create A Viral ...

I use them and I'm sure you have got learn them as well. I am talking approximately ebooks and there is one to hide just about any subject you'll be able to assume of.

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